Abstract

A REVIEW: NOVEL ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF SELECTED ANTICANCER AND ANTIVIRAL DRUGS

Santhosh Illendula* and Naveen Kumar Singhal

ABSTRACT

This review article determines the different analytical methods for the quantitative establishment of selected acalabrutinib, lorlatinib and olaparib and selected antiviral drug molnupiravir by using HPLC and LC-MS/MS. Pharmaceutical analytical method development of acalabrutinib, lorlatinib and olaparib and selected antiviral drug molnupiravir requires valid analytical procedures for quantitative and qualitative analysis in Pharmaceuticals dosage formulations. An Huge survey for determination of acalabrutinib, lorlatinib and olaparib anticancer and selected antiviral drug molnupiravir follow from the research articles published in various pharmaceutical and analytical chemistry Journals. This assessment explain that the superiority of the HPLC/LC-MS methods reviewed is based on the quantitative analysis of drugs in formulations.

Keywords: Method Validation, High performance Liquid Chromatography (HPLC/LCMS), acalabrutinib, lorlatinib, olaparib and molnupiravir.