Abstract

A BRIEF REVIEW OF CARBOXYLIC ACID COCRYSTALS

Qian-Ying Gan and Ren-Wang Jiang*

ABSTRACT

Purpose: The objective of this study is to investigate the major methods for preparation and application of carboxylic acid cocrystals. Methods: The databases including Pubmed, Scifinder and Cambridge Structure Database were searched, and the literature were analyzed. Results: The carboxylic acid is an organic acid that contains a carboxyl group. Bearing both hydrogen bond donors and acceptors, carboxylic acids are excellent coformers for the construction of co-crystals. Different methods including co-crystal in solution, solid state grinding, ultrasound assisted crystallization, melting and crystal sponge can be used to develop carboxylic acid co-crystals, which can improve the solubility, stability, permeability, bioavailability, and biological activity of active pharmaceutical ingredients. Conclusion: Carboxylic acids are excellent coformers for the construction of co-crystals.

Keywords: Carboxylic acid, cocrystals.