Abstract

FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF ORODISPERSIBLE TABLETS OF ONDANSETRON HCL BY DIRECT COMPRESSION METHOD

*Akash Bhardwaj and Dr. Anuj Mittal

ABSTRACT

The reason for this research work is to formulate and evaluate the Orodispersible drug delivery system of the officially utilized therapeutic molecule to enhance the bioavailability and adequacy of the drug. Among ODT drugs, the most encouraging antiemetic is Ondansetron hydrochloride and it was chosen for the present examination. In this way the objective of the present work was to formulate and evaluate Orodispersible tablets of Ondansetron hydrochloride, having satisfactory mechanical strength, quick disintegration, and fast action. Pre-compression parameters like angle of repose, bulk density, tapped density, compressibility index and post- compression parameters like wetting time, water absorption ratio, in-vitro disintegration and in-vitro dispersion time were examined. The hardness, friability and drug content of the considerable number of formulations were observed to be inside the limits.

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