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Abstract

A REVIEW ON SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF THIAZOLIDINE-2,4-DIONE DERIVATIVES

Christeena Mary John*, Dr. Christy K. Jose and Mincy Mathew

ABSTRACT

Thiazolidinedione is a heterocyclic organic compound and is a powerful and clinically important new class of anti-diabetic drugs. Thiazolidinediones are the agonists of peroxisome proliferator activated receptor (PPAR)- γ. Thiazolidinediones possess a numerous biological activity including anti-diabetic, anti-malarial, anti-tubercular, anti-cancer, anti-microbial, anti-inflammatory activities. Therefore, it is required to collect certain recent information in order to understand the pharmacological activities of newly synthesized thiazolidinediones and also to synthesize more active prototypes with efficient activities.

Keywords: Thiazolidinediones, PPAR-?, Anti-diabetic, Anti- microbial, Anti-cancer, Anti-inflammatory, Antitubercular, anti-oxidant, HIV-1-RT inhibitors.


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