Abstract

A WELL EXPLAINED REVIEW ON: EMULSOMES AS VESICULAR DRUG DELIVERY SYSTEM

Amalnath S.*, Ganesh N. S. and Vineeth Chandy

ABSTRACT

Drug can be administered through various routes such as parenteral, oral, rectal, buccal etc. bio availability is the main reason for the selection of various routes, and bio availability is governed by two factors that are solubility and permeability. The bioavailability of lipid soluble drugs can be increased by the enhancement of solubility of those drugs. Formulation of drugs in vesicular drug delivery system (VDDS) can increase the solubility. A VDDS is the system in which encapsulation of active moieties in vesicular structure, which bridges gap between ideal and availability of novel drug delivery system. Different sorts of VDDS like liposomes, neosomes, aquasomes, transferosomes and etc. have increased much consideration, yet emulsomes have been introduced as a system, which sidesteps numerous weakness related with the different systems, created as novel lipoidal VDDS with inward strong fat core encapsulated by phospholipid bilayer. This innovation is intended to go about as vehicle for ineffectively dissolvable lipid drugs. It has a wide range of therapeutic application in case of gene therapy, parenteral drug delivery and also oral formulations. This review explains the concepts of emulsomal drug delivery system. Other factors related to emulsomes such as formulation design, advantages, biopharmaceutical aspects, stability aspects, and various aspects related to drug delivery etc. also well explained.

Keywords: Solubility, Vesicular drug delivery system, Drug delivery, Phospholipid bilayer, Solid fat core, Emulsomes.