Abstract

AN OVERVIEW ON CARRIER MEDIATED NOSE TO BRAIN DRUG DELIVERY SYSTEM

Bhosale Ankush S*, Shaikh Bilal J., Patil Abhishek S., Raut Indrayani D., Nitalikar Manojkumar M.

ABSTRACT

One of the most exciting applications in the field of nasal medication administration is nose-to-brain delivery, which directly addresses the central nervous system while avoiding the blood-brain barrier. Lower doses and direct brain administration of strong drugs are among its advantages, resulting in fewer systemic side effects. Nasal insulin administration showed promising results in Alzheimer's disease clinical trials. Nanomedicines may be able to aid in the realisation of nose-to-brain delivery. While technologies to allow formulation deposition in the upper region of the nose are still needed, surface modification of nanomedicines appears to be the most effective method for increasing medication delivery from the nasal cavity to the brain. This work will describe and critically examine nanomedicine delivery to the nasal epithelium based on particle engineering using surface electrostatic charges, mucoadhesive polymers, or chemical moieties. The mechanism of delivery is nose-to-brain.

Keywords: Nanoparticles, Nose-to-Brain Delivery, CNS Disorders, Mucoadhesion, Neurodegenerative Diseases, Alzheimer’s Disease, Parkinson’s Disease.