Abstract

FORMULATION AND EVALUATION OF HERBAL ANTI-MICROBIAL CREAM CONTAINING HIBISCUS ABELMOSCHUS LINN EXTRACT

Anita R. Desai*, Laxman S. Vijapur, Chetankumar A. Teli and Sachin Terdal

ABSTRACT

Hibiscus abelmoschus fractions has previously demonstrated good antimicrobial & antifungal property, to exploit the above property we have conducted a study by formulating & evaluating the cream containing Hibiscus abelmoschus oil extract and to study of anti-microbial activity, as creams can be easily applied topically & increase contact time and minimize side effects as compare to oral administration. Oil was extracted from the Hibiscus abelmoschus seeds using petroleum ether. Cream was formulated using various excipients like borax, beeswax, white soft paraffin and other additives like methyl paraben, propyl paraben, and distilled water. All the formulations were evaluated for pH, viscosity, extrudability, spreadability, ATR and anti- microbial activity. The ATR spectral analysis suggested that there was no interaction between the drug and formulation additives, pH of formulations were fairly constant about 7.4–7.9 within the range of skin pH. All the cream formulations showed good viscosity, all formulation were spread by applying low share which shows the formulations were having good spreadability. All the formulation was showing good & F2 showed excellent extrudaibility. All the formulation showed good antimicrobial activity, where as F1 & F2 showed good antifungal activity.

Keywords: Hibiscus abelmoschus L, Cream, antimicrobial, antifungal, formulation.