Abstract

AN OVERVIEW ON ANTIFUNGAL AGENTS

Ankita Sharma*, C. P. S. Verma, Pooja Kaushal, Amar Deep Ankalgi and Mahendra Singh Ashawat

ABSTRACT

Fungi are responsible for around 20% of microbiologically documented infections in intensive care units (ICU). Now-a-days, fungal infections are one of the astonishing discoveries of the 20th century. The antifungal drugs are drugs which used in the treatment and prophylaxis of human fungal infections, the antifungals are grouped into five groups on the basis of their rate of action: azoles which inhibit the synthesis of ergosterol polyenes which bind to fungal membrane sterol resulting in the formation of aqueous pores through which essential cytoplasmic material leak out alkylamines, which block ergosterol biosynthesis, leading to accumulation of sequence (which is toxic to the cell): Candins (inhibitors of the fungal cell wall), which function by inhibiting the synthesis of beta 1-3-glucan (the major structural polymer of the); and Flucytosine which inhibits macromolecular synthesis. In last year‟s there are many developments in the diagnose and treatment of fungal disease but still majority of population are developments, many effective antifungal drugs, target the fungal cell membrane and sterol biosynthesis.. A fungal infection also known as mycosis. Although most fungi are harmless to humans, some of them are capable disease under specific conditions. Fungi reproduced by releasing spores that can be picked by direct contact or even inhaled.

Keywords: Antifungal, Classification, Mechanism, Activity and its Techniques.