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  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

DETERMINATION OF THE EFFECT OF FUNCTIONAL HERBAL WATER BLEND IN TYPE-II DIABETES MELLITUS MANAGEMENT

Shiv Vallabhaneni*, Damodar Reddy, C. S. Janaki and Arun Chockalingam

ABSTRACT

Diabliss functional beverages are provided in a water-soluble format to deliver the required efficacy for general health benefits and wellness. Management of type 2 diabetes and controlling high blood sugar levels and their complications is one such health benefits, which is the focus of the current study. Preclinical sub-acute toxicity studies were performed with functional herbal water blend (FHWB) in Wistar rats based on which the human equivalent safe dose was found to be 3.88 g/day. To evaluate the efficacy of FHWB in patients of type 2 diabetes mellitus, single centric, open-label study with 45 subjects for 180 days in five visits was performed with intermediary evaluations at 30 and 90 days as well. Significant and gradual mean reductions with a maximum of 48% in fasting blood sugars (FBS), 44% in postprandial blood sugars and 20.2% in HbA1c in the present study after 180 days indicate the potent efficacy of herbal solution supplementation in the management of type 2 diabetes mellitus among the patients participated in the clinical trial independent of their medication/s profile with anti-diabetic drugs. All other blood, or liver or renal functional and/or lipid profile parameters did not exhibit any significant difference from the corresponding initial visit (0 day) values. FHWB is quantitatively effective and has no side effects and it is easy to store and administer.

Keywords: Diabetes mellitus, functional food and beverage, HbA1c, fasting blood sugar, postprandial blood sugar, sub-acute toxicity study.


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