Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS JANUARY ISSUE PUBLISHED
  • JANUARY 2021 Issue has been successfully launched on 1 January 2021.

Abstract

STUDY OF SOLUBILITY ENHANCEMENT OF GLICLAZIDE BY SOLID DISPERSION TECHNIQUE USING DIFFERENT POLYMERS IN DIFFERENT RATIO

Kanchan Chauhan* and Sunil Dongre

ABSTRACT

The present research describes the solubility enhancement, and drug dissolution of gliclazide as an antidiabetic drug by employing solid dispersion (SD) technique. Solid dispersions formulated with drug and polymers using various polymers such as PEG 6000, PEG 3000 in different ratios such as 1:2,1:3,1:4 respectively by different methods such as fusion method, solvent evaporation method, and microwave irradiation method. The solid dispersion of Gliclazide: PEG 6000 in 1:3 w/w ratio by microwave method showed highest solubility as compared to other methods. Similar results reflected in the dissolution studies where Gliclazide: PEG 6000 in 1:3 w/w ratio showed maximum % drug release, and drug dissolution of 98.77% in 150 minutes, when compared with other formulations and pure drug. From Fourier transform infrared spectroscopy (FTIR) studies, the optimized formulation showed the compatibility between drugs and polymers.

Keywords: Gliclazide, Fusion method, solvent evaporation method, microwave irradiation method, UV, FITR.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More