Abstract

STUDY OF SOLUBILITY ENHANCEMENT OF GLICLAZIDE BY SOLID DISPERSION TECHNIQUE USING DIFFERENT POLYMERS IN DIFFERENT RATIO

Kanchan Chauhan* and Sunil Dongre

ABSTRACT

The present research describes the solubility enhancement, and drug dissolution of gliclazide as an antidiabetic drug by employing solid dispersion (SD) technique. Solid dispersions formulated with drug and polymers using various polymers such as PEG 6000, PEG 3000 in different ratios such as 1:2,1:3,1:4 respectively by different methods such as fusion method, solvent evaporation method, and microwave irradiation method. The solid dispersion of Gliclazide: PEG 6000 in 1:3 w/w ratio by microwave method showed highest solubility as compared to other methods. Similar results reflected in the dissolution studies where Gliclazide: PEG 6000 in 1:3 w/w ratio showed maximum % drug release, and drug dissolution of 98.77% in 150 minutes, when compared with other formulations and pure drug. From Fourier transform infrared spectroscopy (FTIR) studies, the optimized formulation showed the compatibility between drugs and polymers.

Keywords: Gliclazide, Fusion method, solvent evaporation method, microwave irradiation method, UV, FITR.