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  • WJPPS JANUARY ISSUE PUBLISHED
  • JANUARY 2021 Issue has been successfully launched on 1 January 2021.

Abstract

FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILMS

Kshitija P. Deshmukh* and Sayyad Sohail

ABSTRACT

Oral films dissolve rapidly along with drug in mouth and majority of the drug is absorbed through buccal/oral mucosa in to systemic circulation avoiding first pass metabolism. The aim of present investigation was to formulate and evaluate the Fast dissolving oral films (FDOF) of Metoclopramide HCl (anti-emetic drug). Metoclopramide HCl film formulations were prepared by solvent casting technique using HPMC K4M, K15 as film forming polymer and PEG-400 as plasticizer. The prepared films were evaluated for their appearance, thickness, folding endurance, weight uniformity, % drug content, surface pH, tack test, disintegration time and in-vitro dissolution studies.

Keywords: Metoclopramide HCl; fast dissolving oral films; Solvent casting method; In vitro dissolution.


[Full Text Article]

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