Abstract

REMDESIVIR FOR COVID-19: A REVIEW

Anjali Shivaji Shilimkar**

ABSTRACT

In the global pandemic of novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Remdesivir as a drug captured serious worldwide attention. Basically it is nucleoside analogue prodrug, its unique structural features allow high concentration of the active triphosphate metabolite to be delivered intracellularly. Some in vivo and in vitro studies show inhibition of SARS-CoV-2 by the use of remdesivir. The clinical trial of remdesivir is still in progress therefore the further proof to prove remdesivir’s efficacy against COVID-19 is of considerable international concern. Here, I provide an overview of remdesivir’s mechanism of action, clinical usage, in vivo and in vitro studies. Finally, considering the public health and pharmacovigilance approach is also discussed.

Keywords: Remdesivir, COVID-19, SARS-CoV-2, RNA dependent RNA polymerase, GS- 441524.