Abstract

EXPLORING THE ANTIOXIDANT AND WOUND HEALING POTENTIAL OF PIMENTA DIOICA

Prity Kumari, Sandesh Asati* and Vinod Kumar Chandel

ABSTRACT

Wound healing is an intricate process following damage to the skin and other soft tissues of the body. The preliminary qualitative phytochemical screening of the EEPD showed the presence of alkaloids flavonoids, terpenoids, glycosides, and tannins. Quantitative analysis of the EEPD revealed rich amount of phenolic and flavonoidal content in the leaves of Pimenta dioica. Recent studies suggested the valuable role of flavonoids, triterpenoids, and tannins in promoting the wound healing by multiple mechanisms, for example, wound contraction, increased rate of epithelialization, and prevention of secondary bacterial infection that would have complicated and delayed wound healing. In the present study, wound healing potency of EEPD may be attributed to its high phenolics and flavonoidal content owing to their astringent, anti-inflammatory, and antimicrobial activity. Povidone iodine as standard treatment is a well reported agent as antimicrobial and is used to prevent secondary wound infections. The results of the present study revealed that the Ethanolic extract of EEPD contains the phytoconstituents that promote natural healing process and it could be effectively used as a wound healing agent. EEPD ointment efficiently stimulates the wound strength and increases the rate of epithelialization, tensile strength, and collagen viability around the wound area.

Keywords: EEPD; Wound healing; Ethanolic extract; Povidone iodine; Flavaonoid.