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Abstract

SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME NEW- 4-(4-(1H-IMIDAZOL-1-YL)PHENYL)-6-PHENYLPYRIMIDINE-2(1H)-THIONE DERIVATIVES

Zeaba Tabassum*, Syed Azhar Nizami and Gurumurthy M.

ABSTRACT

Imidazole on reaction with 1-(4-chlorophenyl) ethanone in the presence of absolute ethanol gives 1-(4-(-imidazol-1-yl) phenyl) ethanone, condensation of this with various aromatic aldehydes offered 1-(4-(Imidazol-1-yl)phenyl) -3-phenylprop-2-en-1-one, (1), which on cyclization with Thiourea yielded 4-(4-(1H-imidazol-1-yl)phenyl)-6-phenylpyrimidine-2(1H)-thione (2a-2e). The structures of newly synthesized compounds were confirmed by FTIR, 1HNMR, MASS spectral data. Compounds were screened for invitro anti-inflammatory activity by Inhibition of Albumin Denaturation technique and Antiproteinase action. All the synthesized substituted thiopyrimidine compounds have shown moderate to good anti inflammatory activity.

Keywords: Imidazole, 1-(4-chlorophenyl) ethanone, Aromatic aldehydes, Thiourea, Anti-inflammatory activity.


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