Abstract

EFFICACY ON BIOFILMS, EFFECT OF pH AND MECHANISM OF ACTION OF ANTISEPTICS USED IN WOUND HEALING

*Sonal Bhaliya, Dr. Jigar Vyas, Dr. U. M. Upadhyay

ABSTRACT

Antiseptic have broader spectrums of antimicrobial activity than antibiotics and a much lower risk of bacterial resistance selection. Antiseptics are therefore appropriate alternative to antibiotics for the management of localized superficial skin infections. We will review currently available antimicrobials with particular emphasis on providone iodine employed to help suppress biofilms in wounds. Providone iodine has the broadest spectrum of antimicrobial activity of the available antiseptics. We will also review the effect of pH on antimicrobial efficacy. Wound healing is a complex regeneration process, which is characterized by intercalating degradation and reassembly of connective tissue and epidermal layer. The paper reviews the antiseptic agent like PHMB (polyhexamethylene biguanide) & Octenidine are most promising substances available today from a clinical point of view, focusing on efficacy, safety and clinical applications.

Keywords: .