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Abstract

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL 2-SUBSTITUTED BENZIMIDAZOLE SCHIFF BASES AND ITS AZETIDINONE AND THIAZOLIDINONE DERIVATIVES

*Abhay Kumar Verma*, Rashmi kumari, Arun Kumar Singh (Sr.), Rinky Maurya ,Mukesh Chandra Sharma.

ABSTRACT

In the present study, a new series of 2-substituted benzimidazole schiff bases and its azetidinone and thiazolidinone derivatives were synthesized from O-phenylenediamine and P-amino benzoic acid. The synthesized compounds were screened for antibacterial (Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Salmonella typhi), antifungal (Candida albicans and Aspergillus niger), analgesic activity by tail-flick method and anti-inflammatory activity by carrageenan induced paw oedema method. The synthesized compounds showed significant activity of antibacterial, antifungal, analgesic and anti-inflammatory activity comparable to that of standard.

Keywords: Benzimidazole, Azetidinone, Thiazolidinone, Antibacterial, Antifungal, Analgesic, Anti-inflammatory.


[Full Text Article]

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