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Abstract

IN SILICO SEARCH OF SOME CHEAP ANTIBIOTICS-PART-1

*K.K.Srivastava, Shubha Srivastava , Md. Tanweer Alam, Rituraj

ABSTRACT

In search of some cheap antibiotics, molecular docking studies with proteins 1BSK and 1S17 were carried out using certain succinic acid derivatives. Some of the derivatives of succinic acid were found to have binding energy and docking pattern very close to the originally docked molecule in 1BSK and 1S17. The docking result of succinic acid derivatives with the two proteins shows the more effectiveness with some well-known antibiotic such as norfloxacine, Ciprofloxacin and ofloxacin. The quick prop results reveal that these molecules are non-toxic. Some of the succinic acid derivatives shows higher docking score compared to originally docked ligand in 1S17 protein.

Keywords: Molecular docking, 1BSK, 1S17, succinic derivatives, antibiotic ,quick prop, druggability.


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