Abstract

IN VITRO AND IN VIVO ANTIINFLAMMATORY ACTIVITY OF THE METHANOLIC EXTRACT OF CALOCYBE INDICA P.&C.

Prabu M* and Kumuthakalavalli R

ABSTRACT

In vitro and in vivo antiinflammatory activity of Milky mushroom (Calocybe indica) exhibited significant results for its protein denaturation (20.92±0.28 at 1000 μg/ml) and proteinase inhibitory activity (31.55±0.06% at 1000μg/ml) in a dose-dependent manner and in Carrageenan induced acute inflammatory model (48.55% at 200μg/kg body weight). Presence of phytochemicals namely flavonoids, polyphenols, saponins, tannins and terpenes may be responsible for such antiinflammatory activity. These results reveal that, Calocybe indica can be used as a potential antiinflammatory agent.

Keywords: Calocybe indica, antiinflammatory activity, phytochemicals, polyphenols, flavonoids.