Abstract

SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM: A STRATEGY TO IMPROVE ORAL BIOAVAILABILITY

Payal Gupta*, Pramod Kumar Sharma, Nitin Kumar, Yogesh Pawar,Jitendra Gupta

ABSTRACT

Now a day oral route is the easiest and most prominent route for drug delivery. More than 40% of new chemical entities exhibit poor aqueous solubility result in unsatisfactory oral drug delivery. Self nano-emulsifying drug delivery system (SNEDDS) play important role in improvement of bioavailability, by mixture of oil, surfactant, and co-surfactant were prepared under gentle agitation and obtain by pseudo-ternary phase diagram and evaluate on the basis of Zeta size & potential, Conductivity measurement, Turbidity measurement and Trans mission electron microscopy analysis.

Keywords: Self -Nano Emulsify Drug Delivery System, Bioavailability, Surfactant, Solubility.