Abstract

A RP-HPLC METHOD DEVLOPMENT LIFE CYCLE: A REVIEW

Komal N. Dhaigude* and Dyade G. K.

ABSTRACT

The proposed RP-HPLC method employed here proved to be simple, rapid, specific, accurate, precise and robust for estimation of pioglitazone and glimepiride in pure and pharmaceutical dosage form. The sample recoveries in formulations were in good agreement with their respective label claim and they suggested noninterference. A representative chromatogram is shown in figure. The proposed method can thus be used for routine analysis of glimepiride and pioglitazone solid dosage form. The method shows good accurate, precise result for optimized condition in all stages.

Keywords: Method development, Drgrandant, Impurities, Analytical method.