Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS APRIL ISSUE PUBLISHED
  • APRIL 2021 Issue has been successfully launched on 1 April 2021.

Abstract

METHODS OF SOLUBILITY AND DISSOLUTION ENHANCEMENT FOR POORLY WATER SOLUBLE DRUGS: A REVIEW

Md. Mofizur Rahman*, Abul Bashar Ripon Khalipha, Md. A. K. Azad, Sophia Hossainand Sanjida Haque

ABSTRACT

Solubility and dissolution are the rate limiting factors to achieve their desired concentration in systemic circulation for pharmacological response especially poorly water soluble drugs. About 40 % of drugs discovered as noble compound can’t reach higher stage being poorly water soluble. Effectiveness of the drug can be severely insufficient by poor aqueous solubility and some drugs also show side effects due to their poor solubility. For formulation scientist, problem of solubility is a major challenge. For pharmaceutical product development several methods for poorly water soluble drugs are available to circumvent these. These methods are preferred on the basis of certain aspects such as properties of drug under consideration, nature of excipients to be selected, and nature of intended dosage form. Solid dispersion, Micronization, Salt formation, are some of the vital approaches routinely employed to enhance the solubility of poorly water soluble drugs but each approach has some limitation and advantages. Novel techniques like Nano-suspension, Supercritical processing, Cryogenic technology may allow greater opportunities in the delivery of poorly soluble drugs. The solubility behavior of drugs remains one of the most challenging aspects in formulation development. There are several methods are available for solubility and dissolution enhancement of poorly water soluble drugs. Various methods of solubility and dissolution enhancement for poorly water soluble drugs confer in this review.

Keywords: solubility, solid dispersion, BCS Class, Betacyclodextrin


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More