Abstract

REVIEW: ARGINASE INHIBITORS

Ayesha Shaikh*

ABSTRACT

The arginase enzyme catalyses the L-arginine to produce L-ornithine and urea. There are two type of arginase, Arginase1 and Arginase 2. Increasing arginase activity decrease nitric oxide by competing with NO synthases that increases concentration in L-ornithine. Current research data showed arginase inhibition helpful in cardiovascular diseases, hypertension, ischemia reperfusion injury, atherosclerosis, diabetes mellitus, asthma, cancer, immunologically-mediated diseases and leishmaniasis. Recent information on plant-derived compounds and extracts with arginase inhibitory properties. This present review new prospects in order to improve the discovery of novel arginase inhibitors from plant sources.

Keywords: Arginase, L-ornithine, Catalyses, Arginase inhibitors.