Abstract

CHRONIC RENAL FAILURE AND ASSOCIATION WITH PARATHYROID HORMONE AND VITAMIN D

Nashwa Abdelelah Mohamed*, Mohamed Abd-El moniem Mahmoud, Ayman El-Baz El-Agroudy and Abdel-Aziz Fotouh Abdel-Aziz

ABSTRACT

This study included 65 chronic renal failure (CRF) patients and 25 healthy volunteers as normal control group. Deficiency of vitamin D is associated with high level of iPTH leads to development of secondary hyperparathyroidism (sHPT). The levels of 25(OH) D and calcium were significantly lower; on the other hand, the levels of serum phosphorus and iPTH were significantly higher in comparison with those in the control group. It was observed that there were significant negative correlations between serum iPTH and 25(OH) D, Phosphorus and 25(OH) D levels and between serum calcium and phosphorus levels in chronic renal failure patients. On the other hand, there were significant positive correlations between serum calcium and 25(OH) D levels also, between serum iPTH and phosphorus levels.

Keywords: Chronic renal failure, intact parathyroid hormone, Secondary hyperparathyroidism, Vitamin D.