WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

FORMULATION AND CHARAC TERIZATION OF SOLID LIPID NANOPARTICLES OF QUETIAPINE FUMARATE TO IMPROVE SOLUBILITY

Maya Y. Gaikwad*, Amol S. Deshmukh and Vijay R. Mahajan

 

ABSTRACT

Quetiapine fumarate is an antipsychotic drug with plasma half-life 6 hr. and having poor oral bioavailability (9%) because of first pass metabolism. The aim of the present study was to develop an optimal SLN formulation of Quetiapine fumarate to improve solubility and oral bioavailability. Liquid dispersion of SLN were framed with Oleic acid as oil phase, Cremophor RH 40 and Tween 20 as surfactant and Transcutol P as co-surfactant after screening several vehicles. The prepared formulation was constructed by using phase diagram to optimize the system. Solidification of SLN was done by using spray drying technique using Aerosil 200 as solid carrier. The drug release study shows that the release of Quetiapine fumarate was enhanced in SLN formulation as compared to plain drug and marketed formulation. Stability study shows that there was no sign of change in drug content was observed.

Keywords: Pseudoternary phase diagram, Quetiapine fumarate, SLN, Oral bioavailability.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More