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  • JUNE 2020 Issue has been successfully launched on 1 June 2020.

Abstract

FLOATING MICROSPHERES: A REVIEW

Dr. A. Ankarao*, G. Divya, V. Jyothi, G. Gowri Sindhu and Erick

 

ABSTRACT

Floating microspheres (Hollow Microspheres) are gastro-retentive drug delivery systems based on non-effervescent approach. Hollow microspheres are in strict sense, spherical empty particles without core, free flowing powders consisting of proteins or synthetic polymers, ideally having a size in the range 1-1000 micrometer. Gastro-retentive floating microspheres are low-density systems that have sufficient buoyancy to float over gastric contents and remain in stomach for prolonged period. Various gastro retentive dosage forms are available, including tablets, capsules, pills, laminated films, floating microspheres, granules and powders. Floating microspheres have been gaining attention due to the uniform distribution of these multiple-unit dosage forms in the stomach, which results in more reproducible drug absorption and reduced risk of local irritation. The drug is released slowly at desired rate resulting in increased gastric retention with reduced fluctuations in plasma drug concentration. Floating microspheres to improve patient compliance by decreasing dosing frequency, better therapeutic effect of short half-life drugs can be achieved. Enhanced absorption of drugs which solubilize only in stomach, Gastric retention time is increased because of buoyancy. Floating microspheres are prepared by solvent diffusion and evaporation methods to create the hollow inner core. In the present review preparation, methods, characterization, advantages, mechanism of drug release from microspheres, list of polymers, applications and list of the drugs formulated as floating microspheres are discussed.

Keywords: Floating microspheres, Gastro Retention, Short half-life, Solvent diffusion.


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