Abstract

PHYTOCHEMICAL STUDIES AND EVALUATION OF THE HYPOGLYCEMIC ACTIVITY OF THE METHANOLIC EXTRACT OF TETRAPLEURA TETRAPTERA SHEETS ((SCHUMACH & THONN.) TAUB., 1891)

Mawa Traore, Doumbia Idrissa*, Yeo Sounta Oumar, Yapi Houphouet Felix, N’guessan Jean David and Djaman Allico Joseph

ABSTRACT

This study aimed to perform the phytochemical screening and to evaluate the hypoglycemic effect of the methanolic extract of Tetrapleura tetraptera in streptozotocin diabetic rats. Triphytochemistry has shown that the methanolic extract is richer in polyphenols, flavonoid quinones, saponosides, stereol-polyterpens, gallic tannins and catholic tannins but low in alkaloids. After induction of experimental diabetes in male Wistar strain rats by intraperitoneal injection of STZ (50mg / kg), the animals were treated with the methanolic extract of T. tetraptera administered orally at daily doses of 250, 500, 750 mg / kg / bw for 14 days. The results obtained indicate that streptozotocin induced in rats a diabetes characterized by a significant rise in hyperglycemia. However, oral administration of increasing doses of the methanolic extract for 14 days caused a significant decrease in serum glucose concentration. This anti-hyperglycemic effect suggests that T. tetraptera has potential antidiabetic properties that may justify its traditional use in herbal medicine as an antidiabetic agent.

Keywords: Phytochmical studies, Activité Hypoglycémiante, Tetrapleura tetraptera.