Abstract

DEVELOPMENT AND VALIDATION OF ANALYTICAL METHODS FOR SIMULTANEOUS ESTIMATION OF PIOGLITAZONE AND GLIMEPIRIDE IN BULK AND PHARMACEUTICAL DOSAGE FORM

Tejaswini Kande*, Pallavi Dhekale, Supriya Khatal, Priyanka Borude

ABSTRACT

Glimepiride and Pioglitazone in combination are available as tablet dosage forms in the ratio of 2: 15. A simple, reproducible and efficient spectrophotometric method has been developed for the simultaneous estimation of Glimepiride and Pioglitazone in bulk and tablet dosage forms. The proposed method is based on the simultaneous equation method. This mixture was analyzed for getting the spectra from 200-400 nm for Pioglitazone and Glimepiride mixture. The method was validated statistically according the ICH guidelines. The recovery studies confirmed the accuracy of the proposed methods.

Keywords: Pioglitazone, Glimepiride, Validation, recovery studies.