Abstract

A STUDY ON THE SAFETY AND EFFICACY OF COMBINATION OF METFORMIN/TENELIGLIPTIN VS METFORMIN/GLIMEPIRIDE IN TYPE 2 DIABETES MELLITUS PATIENTS IN A TERTIARY CARE HOSPITAL

Jenin Vincent Parambi*, Arya Suresh, Irene T. Ivan, Dr. K. P. Mohanraj, Dr. Sheik Haja Sherief and Dr. T. Shivakumar

ABSTRACT

Background: Diabetes mellitus is the most common endocrine disorder. It is a chronic condition, characterized by hyperglycemia due to impaired insulin secretion with or without insulin resistance. In market many antidiabetic drugs of different classes are available and selection of correct drug regimen for diabetic mellitus by physicians is a crucial step. Objective: To study the safety and efficacy of combination of metformin/teneligliptin vs metformin/glimepiride in type 2 Diabetes mellitus patients in a tertiary care hospital. Methods: A six months prospective observational study was conducted during the period of February 2018 to July 2018, whereby random sample (n=100) of type 2 diabetes mellitus patients was selected. The patients were divided into group A (n=50) taking metformin/teneligliptin (500/20mg) and group B (n=50) taking metformin/glimepiride (500/1mg). The patients six month FBS and PPBS as well as two readings of HbA1c at the start and end of the study were taken. The patients were also monitored for any adverse reactions. Results: Greater reduction in FBS, PPBS and HbA1c was seen in group A when compared to group B. Frequency of adverse drug reaction was similar in both the groups. Conclusion: Metformin/Teneligliptin combination showed better efficacy comparatively and produced significant reduction in FBS, PPBS and HbA1c in shorter period of time than metformin/ glimepiride combination. Both drug combinations were well tolerated in both groups of patients without any significant increase in expected adverse drug reactions.

Keywords: Metformin, Glimepiride, Teneligliptin, Type 2 Diabetes mellitus.