Abstract

A REVIEW ON ANTICANCER ACTIVITY OF PYRIMIDINE DERIVATIVES BY LEUCKART REACTION

E. Ajila*, R. Aniz K. Roy, S. M. Sandhya, Prasobh G. R., M. S. Padmaja Devi, Dhanya S.

ABSTRACT

Leuckart reactions were carried out earlier in the presence of amine, ketones and formic acid. Ketones with solvent free reaction condition, having lesser reaction time using Microwave irradiation and yield higher percentage of products. Leuckart reaction is reductive amination process which converts primary or secondary amine to tertiary amine using protonated ketone and formic acid. This reaction avoids problem of quterization. Pyrimidine is an important heterocyclic molecule is associated with several biological activities. Pyrimidines are heterocyclic compound that have an atom of nitrogen at 1’st and 3’nd position. Pyrimidine is the useful intermediate for the development of many chemotherapeutic agents. It is one of the main pyrimidine nucleuses in anticancer and antiviral agent. Various potent drugs in market contains pyrimidine nucleus like pyrantel pamoate(anthelmintic), flucytosine (antifungal), minoxdil (antihypertension), fluorouracil and floxuridine (antineoplastic), pyrimethamine (antimalarial), idoxuridine and trifluridine (antiviral). The important pyrimidine compounds have diverse applications as bactericidal, fungicidal, analgesic, anti inflammatory, anticancer, antiviral, antimalarial, anthelmintic, antihypertension etc. Pyrimidine ring is also found in vitamin and barbituric acid.

Keywords: Pyrimidine, Anticancer, Leuckart Reaction.