Abstract

SYNTHESIS AND CHARACTERIZATION OF 2, 3-DISUBSTITUTED QUINAZOLINE-4(3H)-ONES AND THEIR POTENTIAL BIOLOGICAL ACTIVITY

M. Ravi*, P. Venkateswara Rao, N. Srinivasa Rao and D. Sri Lakshmi

ABSTRACT

In the present study all the compounds of 2, 3-disubstituted quinazoline -4(3H)-ones from (7a-7g & 8a-8g) were synthesized, characterized and screened for their anti-tubercular and antibacterial activity. The results of anti-tubercular activity revealed that title compounds 7a-e and 8a-c exhibited significant activity. These compounds have amido, thioamido, imidamido, N, N- dimethyl guanidinyl and N-pyridoyl moieties at 3rd position of quinazolinone ring. The study revealed the necessity of synthesizing many more compounds having these moieties. Such compounds may emerge as much more potent anti-tubercular agents. The results of anti-bacterial activity revealed that title compounds 7g and 8d exhibited significant activity against Gram positive bacteria. This may be due to the presence of N-phenyl (7g) and N, N-dimethyl guanidinyl moieties at 3rd position, methyl (7g) and phenyl (8d) at 2nd positions of quinazolinone ring system. From the results, it was observed that none of the title compounds exhibited significant inhibitory activity on the growth of Gram negative bacteria.

Keywords: Quinazoline, 2, 3 Disubstituted Quinazoline, Quinazoline-4(3H)-ones, anti bacterial, anti tubercular.