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Abstract

FORMULATION AND EVALUATION OF TABLET-IN-TABLET DOSAGE FORM CONSISTING OUTER TABLET OF PANTOPRAZOLE AS IMMEDIATE RELEASE AND INNER TABLET OF LEVOSULPIRIDE AS SUSTAINED RELEASE

Sampada Darade* and Kale Pramila

ABSTRACT

The Experiment relates to formulation and development of tablet-in-tablet dosage form consisting outer tablet of pantoprazole as immediate release and inner tablet of levosulpiride as sustained release for administration of therapeutically and prophylactically effective amount of Antipsychotic and proton pump inhibitor drug substance to resist the gastric fluids and obtained both a relatively fast or quick onset of therapeutic effect and maintenance of a therapeutically active plasma concentration for relatively long period of time up to 12hrs. Drug and excipient compatibility study by FTIR analysis and shows the characteristics peaks of API conclude that drug and excipient are compatible with each other. Second stage of formulation development is formulation of immediate release layer and sustained release tablet for preparation of tablet-in- tablet. Formulate immediate release tablet and sustained release tablet individually by dry granulation and wet granulation method. Both tablets pass the Precompression tests and Formulation of tablet-in-tablet using HPMC (K100LV) and CMC in different concentration.

Keywords: Tablet-in-Tablet, Pantoprazole, Levosulpiride, HPMC (K100 LV) and CMC.


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