Abstract

EFFECT OF DIFFERENT PERMEATION ENHANCERS IN TOPICAL DELIVERY OF TINIDAZOLE FROM CARBOPOL BASED GEL

Madhuchandra Lahan* and Bhanu Pratap Sahu

ABSTRACT

Topical delivery is designed to deliver the drug through the skin at a controlled rate to the systemic circulation. The aim of the present study was to investigate the effect of different permeation enhancers on the topical delivery of Carbopol based gel of a model drug Tinidazole. The gel was neutralised by Triethanolamine, and DMSO, PEG and IPM were used as permeation enhancers. The gels were evaluated in terms of pH, viscosity, drug content, drug permeation and its compatibility study. The pH of the gel formulations were found as 7.65-7.84. The viscosity of formulation containing IPM was highest at 4270cp. The drug content was found in the range of 90-95%. In the Drug permeability, PEG showed the maximum release among the three permeation enhancers. The drug compatibility study revealed the absence of any interaction between drug and polymer. The gels were found as homogeneous and showed good result on topical permeation. The results showed that the carbopol can be effectively used as a polymer for topical delivery. The permeation enhancers DMSO, PEG and IPM can be used in the gel for increasing the penetration through skin.

Keywords: Topical gel, Carbopol, Tinidazole, Dimethyl Sulphoxide (DMSO), Polyethylene Glycol (PEG), Isopropyl Myristate (IPM).