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  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2017 Issue has been successfully launched on 1 November 2017

  • ICV
  • WJPPS Rank with Index Copernicus Value 52.51 due to high reputation at International Level

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.041 to 6.647 due to high quality Publication at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
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Abstract

ASSOCIATION OF LIFESTYLE VARIABLES WITH THE NOVEL MUTATION OF BRCA1 GENE IN BREAST CANCER: A CASECONTROL STUDY AMONG THE BENGALEE HINDU FEMALES OF WEST BENGAL, INDIA.

Abhishikta Ghosh Roy*, Pulakes Purkait, Malay Barman, Biswanath Sarkar and Arup Ratan Bandyopadhyay

ABSTRACT

BRCA1 mutations dramatically increase breast cancer risk, which is the commonest cause of female death globally including India. There is a substantial inter-individual variability in breast cancer risk among BRCA1 mutation carriers, which attracts attention of medical genetics. In the present study we have identified a novel mutation (cd.1437 CCT>CTT) in BRCA1 gene that changes the amino acid from Proline to Leucine. Certain lifestyle factors like oral contraceptive use and abortions are found to be highly associated with breast cancer risk among the carriers of germline mutation. This study is the first report from West Bengal among the Bengalee Hindu Caste Female Breast Cancer patients, which would help in early prognosis of the mutation and modification of lifestyle factors.

Keywords: Novel Mutation, Breast Cancer, Lifestyle factors, Bengalee Hindu females, West Bengal, India.


[Full Text Article]

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