Abstract

MOLECULAR TARGETS OF NEW DRUGS FOR PREVENTION SKIN CANCER

Mauricio Alexandre Reis Junior*, Juliana de Santana Reis, Jonata Augusto de Oliveira and Marcos Antonio Corrêa

ABSTRACT

Excessive exposure to sunlight is the main factor responsible for the development of skin cancer. According to the annual statistics provided by the INCA (National Cancer Institute), the number of cases of skin cancer increases gradually as a result of the destruction of the ozone layer and exposure to solar radiation. Solar radiation is responsible for forming of reactive oxygen species that promote: reducing collagen synthesis, causing photoaging; mutation in the DNA, RNA and p53 gene responsible for cell cycle control and apoptosis. Several studies have shown that resveratrol acts the free radical scavenger by transferring the proton from its phenolic group to the free radicals. Furthermore, it was demonstrated reduced signaling NF-kB, TNF and IL-1β. The objective of this review is extends our knowledge about the mechanisms of action of resveratrol and analogues for prevention skin cancer.

Keywords: skin cancer, antioxidant, photoprotection, resveratrol.