Abstract

EXTRACTION AND CHARACTERIZATION OF FLAX SEED MUCILAGE AS PHARMACEUTICAL ADJUVANT

Kirti Rani*, Nayyar Parvez and Pramod Kumar Sharma

ABSTRACT

The objective of the study was to characterize and evaluate flax seed mucilage as Pharmaceutical adjuvant. The mucilage was extracted using distilled water and isolated by acetone. Different parameters such as tests for carbohydrates, protein, fat, reducing and nonreducing sugars, alkaloids, tannins, phenolic compounds and other parameters like micromeritic properties, surface tension, swelling index and viscosity were evaluated for characterizing the extracted mucilage. The result shows that the extraction of mucilage with water has excellent flow properties. Various phytochemical tests show that carbohydrates and amino acids were only present. The pH and surface tension of 1% solution of mucilage was found to be 5.01±0.02 and 65.21 ± 0.734, respectively. It has a good swelling index of 48.8% ± 0.3%. Extracted mucilage is soluble in cold water. The results of evaluated parameters showed that flax seed mucilage has satisfactory pH and physicochemical properties, which can be used as pharmaceutical adjuvant in the formulation of various dosage forms.

Keywords: flax seed Mucilage, seed excipient, superdisintegrant.