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Abstract

A NOVEL HPLC ESTIMATION TECHNIQUE FOR THE ANTIEPILEPTIC DRUG LEVETIRACETAM IN TABLET AND HUMAN URINE SAMPLES

Manoj G Tyagi*, S. Kannan, A S Manickam and JSJU Chander

ABSTRACT

A simple, HPLC method was developed and validated for the assay of Levetiracetam in drug formulations and urine samples. Isocratic elution at a flow rate of 1.0ml/min was conducted on a Phenomenex C18 (Luna® 5 μm C18(2) 100 Å, LC Column 250 x 4.6 mm) at room temperature. The mobile phase consisted of Methanol: Water:TEA 70:25:05 (V/V). The UV detection wavelength was 224 nm and 20μl sample was injected. The retention time for Levetiracetam was 3.02 min. The percentage RSD for precision and accuracy of the method was found to be less than 3%. The method was validated as per the ICH guidelines. The method can be successfully applied for routine analysis of Levetiracetam in tablet dosage form and bulk drug as well in the urine samples.

Keywords: Levetiracetam, HPLC, UV detection, recovery, tablet, mobile phase.


[Full Text Article]

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