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Abstract

IN-VIVO NEPHROPROTECTIVE POTENTIAL FROM LEAVES EXTRACTS OF ANDROGRAPHIS PANICULATA

K. Padmalochana* and M.S. Dhana Rajan

ABSTRACT

Nephrotoxicity is the third most common problemof the renal system. Medicinal plants potentially useful for the treatment of severe renal disorders. In the present study, the effect of aqueous, ethanol and acetone extract of Andrographis paniculata leaves was evaluated by pretreating three groups of rat animals. Renal failure was induced by antibiotic drug gentamicin which was orally administered to group II animals and untreated control model was maintained. After oral administration for 10 days, serum levels of urea, uric acid, creatinine and total protein were assayed. All the biochemical parameters were significantly controlled (p<0.01 and p<0.001) on 10th day after the treatment of aqueous, ethanol and acetone extracts as compared than the gentamicin induced nephrotoxic animals (p<0.05). Maximum nephroprotection was offered by the ethanol extract of A. paniculata leaves (p<0.001). The histological structure of renal was observed by staining with haemotoxylin- eosin viewed using light microscope. Gentamicin treated animals showed acute tubular necrosis due the injury in kidney. In aqueous, ethanol and acetone extract treated animals showed histopathological changes in renal revealed the nephroprotective activity of A. paniculata leaves. Finally, ethanol extract of A. paniculata was more suitable for nephroprotective action against gentamicin induced renal failure was evidenced by biochemical estimation and by restoration of histological changes of renal system.

Keywords: Kidney, A. paniculata, Herbal medicine.


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