Photo Gallery



News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • JUNE 2021 Issue has been successfully launched on 1 June 2021.



K. Padmalochana* and M.S. Dhana Rajan


Nephrotoxicity is the third most common problemof the renal system. Medicinal plants potentially useful for the treatment of severe renal disorders. In the present study, the effect of aqueous, ethanol and acetone extract of Andrographis paniculata leaves was evaluated by pretreating three groups of rat animals. Renal failure was induced by antibiotic drug gentamicin which was orally administered to group II animals and untreated control model was maintained. After oral administration for 10 days, serum levels of urea, uric acid, creatinine and total protein were assayed. All the biochemical parameters were significantly controlled (p<0.01 and p<0.001) on 10th day after the treatment of aqueous, ethanol and acetone extracts as compared than the gentamicin induced nephrotoxic animals (p<0.05). Maximum nephroprotection was offered by the ethanol extract of A. paniculata leaves (p<0.001). The histological structure of renal was observed by staining with haemotoxylin- eosin viewed using light microscope. Gentamicin treated animals showed acute tubular necrosis due the injury in kidney. In aqueous, ethanol and acetone extract treated animals showed histopathological changes in renal revealed the nephroprotective activity of A. paniculata leaves. Finally, ethanol extract of A. paniculata was more suitable for nephroprotective action against gentamicin induced renal failure was evidenced by biochemical estimation and by restoration of histological changes of renal system.

Keywords: Kidney, A. paniculata, Herbal medicine.

[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More