Abstract

MICROSPONGES: A NOVEL DRUG DELIVERY SYSTEM

Ganesh S. Bamane*, Tejaswini B.Kakade, Vijay B.Metkari, Laxmikant V.Kulkarni

ABSTRACT

Microsponges are porous, polymeric microspheres that are mostly used for prolonged topical administration. Microsponges are designed to deliver a pharmaceutically active ingredient efficiently at minimum dose and also to enhance stability, reduce side effects, and modify drug release profiles. The Microsponge Delivery System (MDS) is a unique technology for the controlled release of topical agents and consist of macro porous beads, typically 10-25 microns in a diameter, loaded with active agent. When applied to the skin, the Microsponge releases its active ingredient on a time mode and also in response to other stimuli (rubbing, pH, etc.). MDS technology is being used currently in cosmetics, over the counter (OTC) skin care, sunscreens and prescription products. Conventional preparations have some disadvantages like unpleasant odour, greasiness and skin irritation. These problems are overcome by microsponge delivery system. Microsponge based drug delivery system produces controlled released action. It also produces site specific and target organ action produced. Microsponge (MDS) mainly developed in topical drug delivery as well as oral controlled delivery system. It also used in cosmetic formulations.

Keywords: Microsponges, drug delivery, preparation, characterization, topical, oral.