Abstract

FORMULATION AND EVALUATION OF SUSPENSION CONTAINING CHLOROQUINE SULPHATE-LOADED EUDRAGIT EPO MICROSPHERES

Madgulkar AR*, Bhalekar MR, Padalkar RR. and Kulangi SL

ABSTRACT

The objective of this work was to develop and evaluate suspension of taste masked microspheres of chloroquine sulphate. The microspheres were prepared by the solvent evaporation technique using pH sensitive polymer Eudragit EPO. Guar gum was used as suspending agent. Prepared suspension formulations were tested for sedimentation rate, in vitro drug release and taste masking. This result indicated that no leakage of drug occurred from the microspheres in the suspension on storage. Moreover the same release rate of chloroquine sulphate from the microspheres suspension and microspheres alone, indicated that the suspension medium studied did not affect the property of drug release. Thus, results conclusively demonstrated successful taste masking and formulation of suspension with taste masked microsphere especially for pediatric patients.

Keywords: Chloroquine sulphate, taste masked microspheres, suspension, in vitro drug release profile.