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Abstract

SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITIESPREDICTION AND EXPERIMENTAL VALIDATION FOR SOME PYRIDINE CONTAINING HYDROXYTRIAZENES

Ashok Kumar Patidar, Ajay Kumar Goswami*, Sharad Sharma, Anita Mehta, Amit Bhargava

ABSTRACT

In-silico prediction of newly synthesized compounds and their experimental validation has recently attracted attention of researchers. PASS (Prediction of Activity Spectra for Substances) is a very simple tool for prediction of probable activity theoretically on the basis of molecular structure. In the present study, a series of hydroxytriazenes (4a-h) have been synthesized and characterized through their spectral and physical analysis. All synthesized compounds have been screened for probable activities using PASS (http://pharmaexpert.ru/passonline/) and have Pa value in the range of 95.2% to 80.9% indicating their excellent probability to have antiinflammatory activity. In view of this synthesized compounds have been used to validate anti-inflammatory activities as predicted by PASS. It is first such attempt to use In-silico prediction before synthesis and test validity of PASS for designing drugs with respect to hydroxytriazenes.

Keywords: Hydroxytriazenes, Pyridine, PASS and Activity prediction, anti-inflammatory activity.


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