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Dipanshi Gour*, Dr. Vinay Pandit and Dr. M. S. Ashawat


Solvency is one of the significant parameter to accomplish the ideal concentration of drug in systemic for a pharmacological reaction to appear. Drug efficacy can be seriously restricted by poor watery dissolvability and a few drugs likewise show side effect because of their poor solvency. Numerous strategies are utilized to improve watery dissolvability. The capacity to increment watery dissolvability would thus be able to be an important aid to enhance the efficiency or reducing side effects for specific drugs. This is valid for parentally, topically and orally administrated solutions. The utilization of the solvency attributes in bioavailability, pharmacological activity and dissolvability improvement of different inadequately solvent mixtures is a difficult task for analysts and drug researchers. Hydrotropy is one of the dissolvability improvement strategies which upgrade solvency to numerous folds with the utilization of hydrotropes like sodium benzoate, sodium citrate, urea, niacinamide etc and have numerous benefits as, it doesn't need chemical modification of hydrophobic drugs, utilization of natural solvents or arrangement of emulsion framework and so on.

Keywords: Hydrotropy, Solvency, Hydrophobic drugs, Hydrotropes, Mixed Hydrotropes.

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