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Abstract

FORMULATION AND EVALUATION OF TASTE MASKED CHEWABLE TABLETS OF MEBENDAZOLE

Barde Lokesh G., Mahajan Nilesh S.*, Deo Swapnil D. and Swati Dattatraya Yeole

ABSTRACT

The aim of this research was to mask the bitter taste of Mebendazole using ion exchange resin and to formulate a taste masked chewable tablet. Kyron T-114 was used as a taste masking agent which was containing cross-linked poly-acrylic backbone was used as taste masking agents. The drug resin complex was prepared by complexation of drug with resin using batch method. Maximum drug loading capacity of resins Kyron T-114 was calculated then Drug Resin Complexes were optimized by effect of drug resin ratio, Effect of steering time. Effect of soaking time, effect of temperature and effect of pH on drug loading. Drug resin complex was evaluate for FTIR studies, drug release at salivary pH 6.8 and dissolution of drug resin complex at gastric pH. Taste masked chewable tablets of Mebendazole were prepared by direct compression method. Post compression evaluations used such as thickness, diameter, weight variation, hardness, disintegrating test, content uniformity test and in vitro dissolution test.

Keywords: Mebendazole, Kyron T-114, taste masking, ion exchange resin.


[Full Text Article]

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