Abstract

GLIPIZIDE (POORLY WATER SOLUBLE DRUG) – ENHANCEMENT OF SOLUBILITY BY VARIOUS SOLUBILIZATION TECHNOLOGY

Ayushi Jain*, Rama Shukla, A. K. Singhai

ABSTRACT

Glipizide is an oral, rapid and short acting anti diabetic drug. It is classified as a second generation sulfonylurea. It is used for treatment of type-II diabetes mellitus. Its BCS Class-II drug. Due to poor solubility of drug, its bioavailability rate is limited by drug dissolution. Improve the solubility of drug we are using different solubility method such as solid dispersion method, hydrotrophy and micellar solubilization. Solid dispersion, describe as the dispersion of one or more active pharmaceutical ingredient in a carrier at solid state and an efficient technique to increase solubility of poorly water-soluble drug to enhance their bioavailability. Hydrotrophy refers to increasing the water solubility of drug by hydrotrophy agent(Urea, Surfactant, Alkaloids). Micellar solubilization. The use of surfactant to improve the dissolution performance of poorly soluble drug products. Surfactant reduce surface tension and increase the solubility of lipophilic drug in aqueous medium.

Keywords: Diabetes, Glipizide -drug, BCS Classification, Dissolution method.