Abstract

REVIEW ON ANALYTICAL METHOD OF DOXOFYLLINE AND ERDOSTEINE

Mistry Rujuta* and Mandale Drasti

ABSTRACT

Bronchiectasis is a long term condition where the airways of the lungs become abnormally widened leading to a buildup of excess mucus that can make the lungs more vulnerable to infection. Combination of a bronchodilator and an anti-inflammatory is used for treating bronchiectasis. Doxofylline is a important constituent in a successful treatment for bronchiectasis since it safely creates bronchodilation and anti-inflammatory effects in one drug. Effective clearance of mucus from the airways is one of the most important, perhaps crucial, treatment modalities that can be instituted in patients with bronchiectasis so erdosteine is mucolytic approved for treating COPD. The combination of Doxofylline and Erdosteine will provide synergistic treatments for bronchiectasis. Many analytical methods are developed for Doxofylline and Erdosteine. Doxofylline is official in IP and other methods like UV, HPLC, RP-HPLC, Stability indicating RP-HPLC, LC-MS/MS are also developed. Erdosteine is not official in any pharmacopeia but UV, HPLC, RP-HPLC, HPTLC, Stability indicating RP-HPLC, LC-MS/MS developed for Erdosteine. In combination for both drugs no method is developed till now.

Keywords: Doxofylline, Erdosteine, bronchiectasis, analytical methods.