Abstract

A TOXICITY STUDY ON LINGA CHENDURAM

Aruljothi R.* and Thiruthani M.

ABSTRACT

The aim and objective of the study was to prepare and evaluate the safety of Linga Chenduram in animal model. Linga chenduram was prepared by standard operative procedure mentioned in siddha text. To evaluate its safety acute and 28days repeated oral toxicity studies were performed following OECD guidelines 423 & 407 respectively. In acute toxicity study, the animals were treated with Linga chenduram 2000 mg/kg were showed tolerance with negligible toxic signs. From Acute Toxicity Study, 1/10 & 2/10 of maximum tolerated dose ie 200mg&400mg/kg, were selected for further 28days repeated oral toxicity study.

Keywords: Metals, Linga Chenduram, Acute and Sub-Acute Toxicity.