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Abstract

FORMULATION AND EVALUATION OF MATRIX TABLET OF GLIMEPIRIDE BY USING TAMARIND SEED POLYSACCHARIDE

Abdulsalam Alhalmi*, Prabhjot Ahuja, Marwan Altowairi and Puneet Utreja

ABSTRACT

In the present study, an attempt was made to prepare and evaluate sustained release matrix tablets of glimepiride by using natural polymer, tamarind seed polysaccharide, which isolated from Tamarindus indica seeds, in order to improve efficacy, reduce the frequency of administration, and better patient compliance. The prepared blend granules were evaluated for angle of repose, tapped density, bulk density, carr’s index and hausner’s ratio. The tablets were tested for hardness, weight uniformity, friability, content of drug, swelling, in vitro dissolution studies and kinetic data analysis. The obtained results were clearly indicating that the formulated tablets results are within the pharmacopeial range. In vitro drug release and kinetics studies for all batches were performed. The optimized formulations F2 showed maximum drug release of 93.5% over a period of after 24 hours. All formulations except F1 followed Kosmeyer - Peppas model which indicated that the mechanism of drug release of formulations F2 to F5 was anomalous transport (Non-Fickian) diffusion. The optimized formulations F2 and F3 was best fitted to Kosmeyer-Peppas as the plot showed highest linearity (R² = 0.9753 and 0.9844).

Keywords: Glimepiride, tamarind.


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