FORMULATION DEVELOPMENT AND EVALUAATION OF CANDESARTAN CILEXETIL IMMEDIATE RELEASE TABLETS
Yellareddy Challa*, Sujatha. Banavath, Alle. Swathi, Ragya Eslavath, Ubbani Ramakrishna, R.Suthakaran and Kalyankar Manasvi Jyothirmai
ABSTRACT
The tablets were prepared and evaluated using wet granulation technique. In order to optimize the product, different formulations were developed. And pre compression and post compression were evaluated .To check the compatibility of drug with various polymers,. FTIR spectra of Candesartan Cilexetil were recorded, The IR spectral analysis of Candesartan Cilexetil pure drug alone showed that principal peaks were observed at wave numbers 2939.13 cm-1, 1752.03 cm-1, 1546.56 cm-1, 1713.38 cm-1 and 1573.01 cmthe major peaks were observed at 2937.48 cm-1, 1752.22 cm-1, 1546.30 cm-1, 1713.10 cm-1 and 1573.28 cm-1.. All the formulations were evaluated for physical
characteristics, Disintegration, in-vitro Dissolution and Stability studies. The Formulation F8 showed fair flow properties when compared to the reference product.From the obtained in vitro results of the above formulation Trials, We selected F - 8 as the optimized formulation because it showed total drug release with in 30 min than all other formulations and reference product.
Keywords: Candesartan, Carboxy methya cellulose, invitro studies and accelerated stability studies.
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