Abstract

REVIEW ON: SYNTHESIS AND BIOLOGICAL EVALUATION OF DIFFERENT BENZOTHIAZOLE DERIVATIVES

Harendar Kumar Nivatya*, Ranjeeta Verma, Amit Singh, Shruti Varshney, Neeraj Kumar Fuloria and Shivkanya Fuloria

ABSTRACT

Benzothiazole is aromatic compound most effective ion heterocyclic classes with molecular fomula C7H5NS. It is colorless, gradual viscous liquid. The reported activities are most effective substituted derivatives. These derivatives are synthesis of benzothiazole moiety which comprises with different biological activities. In this review the different benzothiazole derivatives compound as synthesis of 2-[2-(N,N-dichloroethylamino)-4-fluorophenyl]-benzothiazole or synthesis of 2-amino acetate, 6-chloro benzothiazole are made to synthesize by large number of efforts and their other derivatives were found to posses antimicrobial, anti-inflammatory, anticonvulsant, anti-helminitic, antidiabetic, antitumor, cyclooxygenase inhibitor, anti-
alzheimers and antimalarial activities. Benzothiazole moiety is very small but it possesses different biological activities but not only benzothiazoles but its different substituted derivatives also give different biological activities. Benzothiazoles are remarkably effective compounds after extensive structural modification. These are most effective against different strains of microorganisms. This review is focused on the benzothiazole moiety and its different derivatives that posses different biological activities. Among these heterocyclic 1,3-benzothiazole derivatives that attracted considerable attention in the research sector of synthesis, because of its potent and significant pharmacological activities.

Keywords: Benzothiazole derivatives, Anti-inflammatory, Anti-microbial and Antihelmintic.