Abstract

FORMULATION AND CHARACTERIZATION OF OIL NANO-EMULSION BASED GEL FOR DERMATOLOGICAL APPLICATION

Ravi Patel*

ABSTRACT

Essential oil are one of the most notorious natural products used for medical purposes. Collective with their popular use in dermatology. The spontaneous emulsification, micro fluidization and ultra-sonication were compared at same Geranium oil (GO) %, at higher Geranium oil Concentrations (2, 4, 6, 8 and 10%), results were not significantly different for particle sizes. Moreover, for all GO concentrations, antimicrobial activity could not be enhanced by micro fluidization towards S. aureus. However, at higher GO concentration (8 and 10%), enhanced antimicrobial activity were obtained by spontaneous emulsification and ultra-sonication methods, and these results were not found to be significantly different (p>0.05). This study revealed that RO could successfully be utilized as carrier oil for preparing Nano-emulsions and stable Geranium oil Nano emulsions could be prepared at lower surfactant concentrations by the spontaneous emulsification method. It concludes the geranium oil was used as a potential antimicrobial agent for skin.

Keywords: Geranium oil, Rosewood oil, Nano emulsion and Antimicrobial activity.