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Abstract

DEVELOPMENT, OPTIMIZATION AND EVALUATION OF FAST DISSOLVING ORAL FILM

Bidkar S. J.*, Abhishek D. Meher * and Dr. G. Y. Dama

ABSTRACT

Recently, Fast-Dissolving Drug Delivery Systems Have Started Gaining Fame And Acceptance As New Drug Delivery Systems, Which Aim To Enhance Safety And Efficacy Of A Drug Molecule By Formulating It Into A Conventional Oral Dosage Form for Administration And To Achieve Better Patient Compliance. Cinnarizine is a piperazine derivative and is widely prescribed for the treatment of vestibular disorders and motion sickness. To enhance the anti-emetic and anti-migraine properties of Cinnarizine it is desirable to develop its fast acting dosage form hence a fast mouth dissolving film of Cinnarizine is always a better choice. These conditions require a delivery system capable of delivering the drug rapidly for immediate relief without the need of water. The films were prepared by solvent casting technique. The 32 factorial design was applied for optimization of concentration of polymer Pectinand plasticizer glycerin. The prepared films were evaluated for various parameters related to delivery system like thickness, tensile strength, % elongation, folding endurance, disintegration time, drug content, In vitro release study and stability study. Among the all Formulation, Batch F5used pectin 750 mg (15%) and plasticizer glycerin 0.9 ml were releaseupto 98.20 % of the drug from the film 24 sec. Which exhibit faster absorption and desirable characteristic of film compare than other formulation.

Keywords: Oral fast dissolving film, cinnarizine, motion sickness, menier’s disease, Pectine, Glycerin, solvent casting method.


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